? 設(shè)計、構(gòu)建、表達新型多特異性抗體
? 采用多種純化技術(shù)（親和、離子交換、分子篩等）進行抗體純化與優(yōu)化
? 通過生化與生物物理方法（SDS-PAGE、SEC-HPLC、BLI/SPR親和力測定）檢測抗體純度與特性
? 利用多種細胞（AML細胞、效應(yīng)細胞等）和多種平臺技術(shù)（流式細胞術(shù)、ELISA）對多特異抗體展開功能及細胞毒性評估
? 分析實驗數(shù)據(jù)、完善研究記錄，并定期在實驗室會議與學(xué)術(shù)會議上匯報成果
? 撰寫優(yōu)質(zhì)學(xué)術(shù)論文

? Design, construct, and express novel multispecific antibodies using mammalian expression systems (e.g., HEK293, CHO cells)
? Optimize and perform antibody purification using various chromatographic techniques (affinity, ion-exchange, size-exclusion)
? Characterize antibody properties using biochemical and biophysical methods (SDS-PAGE, SEC-HPLC, BLI/SPR for affinity measurements)
? Evaluate antibody functionality through comprehensive in vitro assays including binding assessments (flow cytometry, ELISA) and cytotoxicity studies using primary AML cells and effector cells
? Analyze experimental data, maintain detailed documentation, and present findings at lab meetings and scientific conferences
? Prepare manuscripts for publication in high-impact journals

? 近期或即將獲得生物化學(xué)、分子生物學(xué)、免疫學(xué)、生物工程等相關(guān)領(lǐng)域博士學(xué)位
? 具備分子生物學(xué)技術(shù)實戰(zhàn)經(jīng)驗（PCR、克隆、質(zhì)粒設(shè)計與制備）
? 擁有蛋白質(zhì)表達與純化（?KTA SEC-FPLC）的經(jīng)驗
? 熟練掌握細胞實驗技術(shù)（細胞培養(yǎng)、轉(zhuǎn)染、流式細胞術(shù)、功能實驗）
? 以第一作者在同行評審期刊發(fā)表過多篇論文
? 具有獨立科研與解決問題能力
? 團隊協(xié)作能力
? 中英文雙語工作能力（書面與口語）

? Recently awarded or upcoming Ph.D. in Biochemistry, Molecular Biology, Immunology, Bioengineering, or related field
? Extensive hands-on experience with molecular biology techniques (PCR, cloning, plasmid design and preparation)
? Demonstrated expertise in protein expression (transient/stable transfection) and purification (?KTA FPLC systems)
? Proficiency with cell-based assays (cell culture, transfection, flow cytometry, functional assays)
? Strong publication record with first-author papers in peer-reviewed journals
? Excellent problem-solving abilities and capacity for independent research
? Ability to work effectively in a collaborative team environment
? Fluency in both English and Chinese (written and verbal)

應(yīng)聘材料：
1.Cover Letter：闡述研究方向、職業(yè)規(guī)劃及崗位適配性
2.詳細簡歷（含出版物列表）
3.三位推薦人的聯(lián)系方式

我們提供：
? 具有競爭力的薪酬與完善福利待遇（根據(jù)資歷核定）
? 對博士后的職業(yè)發(fā)展提供幫助
? 尖端核心設(shè)施支持（流式細胞儀、共聚焦顯微鏡、Biacore、AKTA、動物模型與臨床樣本平臺）
? 跨學(xué)科、支持性、動態(tài)化的科研環(huán)境
? 學(xué)術(shù)交流與會議參會機會

We Offer:
? Competitive salary and comprehensive benefits package commensurate with experience
? Dedicated mentorship focused on career development in academia or industry
? Access to state-of-the-art core facilities (flow cytometry, microscopy, Biacore, AKTA, animal models, and clinical samples)
? Dynamic, supportive, and interdisciplinary research environment
? Opportunities for professional networking and conference travel
Application Process:
Please submit the following materials as a single PDF file to [Email Address] with the subject line "Postdoc Application: Cover letter outlining research interests, career goals, and specific qualifications for this position
1.Current CV including publication list
2.Contact information for three professional references