The Department of Pharmacology and Neuroscience, Creighton University School of Medicine, is seeking two research scientists or postdoctoral fellows for an NIH funded project.
美國克萊頓大學醫(yī)學院藥理學和神經科學系正在為美國國立衛(wèi)生研究院資助的項目尋找兩名研究科學家或博士后研究員。
01.關鍵職責
Airway hyperresponsiveness and airway inflammation are hallmarks of asthma that is clinically managed with β2-agonist bronchodilators and inhaled corticosteroids. Refractory asthma manifests with persistent symptoms despite the use of high-dose oral corticosteroids and long-acting β2-agonists and poses a major healthcare challenge. Understanding the molecular mechanisms of therapeutic resistance and developing strategies to overcome such resistance poses a significant unmet need.
氣道反應過高和氣道炎癥是哮喘的標志，通過β2激動劑支氣管擴張劑和吸入皮質類固醇進行臨床治療。盡管使用大劑量口服皮質類固醇和長效β2激動劑，但難治性哮喘仍然表現出持續(xù)的癥狀，并構成了重大的醫(yī)療保健挑戰(zhàn)。了解治療耐藥性的分子機制并制定克服這種耐藥性的策略，是重大的未滿足需求。
1.We are seeking talented, highly motivated individuals who are broadly interested in the molecular and cellular basis of refractory asthma. Our research focuses on understanding the molecular mechanisms of therapeutic resistance and developing new strategies to overcome such resistance in refractory asthma.
1，我們正在尋找對難治性哮喘的分子和細胞基礎廣泛感興趣的有才華、積極性高的人。研究重點是了解治療耐藥性的分子機制，并制定新的策略來克服難治性哮喘的這種耐藥性。2.Ideal candidate will be expected to develop the project independently and will also have the opportunity to interact and participate in other studies of our multidisciplinary group in the lab and throughout the department. Our research team highly values creativity and independence in a collaborative and collegial academic environment.
2，理想的候選人有望獨立開發(fā)該項目，并有機會在實驗室和整個部門互動和參與我們多學科小組的其他研究。我們的研究團隊高度重視在協作和合議學術環(huán)境中的創(chuàng)造力和獨立性。
3.Successful candidates will have a doctorate in areas related to cell and molecular biology, immunology, signal transduction, asthma or cancer, supported by strong publications. Prior experience in airway smooth muscle cells and mouse models of asthma and/or cancer would be advantageous.
3，成功的候選人將獲得細胞和分子生物學、免疫學、信號轉導、哮喘或癌癥相關領域的博士學位，并得到強有力的出版物的支持。之前在氣道平滑肌細胞和哮喘和/或癌癥的小鼠模型方面的經驗將是有利的。
4.Candidates will also be asked to assist in training of laboratory staff and graduate students in research techniques as well as writing grant proposals. This is a full time, grant funded role.
4，候選人還將可以協助培訓實驗室工作人員和研究生研究技術以及撰寫贈款提案，這是一個全職、贈款資助的角色。
02.申請資格
?Applicants should have a Ph.D., M.D., or M.D./Ph.D. degree
?申請人應擁有博士學位、醫(yī)學博士學位或醫(yī)學博士學位/博士學位
? Significant research accomplishments and scholarly promise
?重要的研究成就和學術前景
03.如何申請
Applicants can send the following materials to Prof. Yaping Tu
(Yat60399@creighton.edu).
1.Curriculum vitae
2.A brief summary of research to date and preferred research directions for the next few years
3.Names of three referees who can write letters of recommendation (at least one outside the applicant’s home institution)
申請人可以將以下材料發(fā)送給Yaping Tu教授（Yat60399@creighton.edu）。
1.簡歷
2.迄今為止的研究摘要和未來幾年的首選研究方向
3.三名可以寫推薦信的推薦人的姓名（至少在申請人所在地機構外有一名）
美國克萊頓大學是一所位于美國內布拉斯加州奧馬哈的私立研究型大學。它成立于1878年，在2022-2023年版的最佳學院中排名第115位，在美國最具價值學校中排名第90位。
